Kazuaki Nonaka Selected Research

Genee-Wiedemann syndrome

1/2016	Dihydroorotate dehydrogenase depletion hampers mitochondrial function and osteogenic differentiation in osteoblasts.
2/2013	Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction.
12/2012	Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Kazuaki Nonaka Research Topics

Disease

3	Mitochondrial Diseases (Mitochondrial Disease) 11/2017 - 02/2013
3	Genee-Wiedemann syndrome 01/2016 - 12/2012
2	Liver Cirrhosis (Hepatic Cirrhosis) 04/2019 - 09/2015
2	Osteoporosis 05/2015 - 01/2012
1	Hyperalgesia 10/2021
1	Pain (Aches) 10/2021
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 11/2019
1	Biliary Atresia 04/2019
1	Diaphragmatic Hernia 04/2019
1	Acute Liver Failure (Fulminant Hepatic Failure) 01/2019
1	Hepatolenticular Degeneration (Wilson's Disease) 01/2019
1	Metabolic Diseases (Metabolic Disease) 01/2019
1	Periventricular Leukomalacia (Neonatal Cerebral Leukomalacia) 12/2018
1	Patent Ductus Arteriosus 12/2018
1	Hemorrhage 12/2018
1	Necrotizing Enterocolitis 12/2018
1	Metabolic Bone Diseases (Osteopenia) 11/2018
1	Hyperbilirubinemia 11/2018
1	Tooth Abnormalities 11/2018
1	Cognitive Dysfunction 08/2018
1	Rett Syndrome (Rett's Disorder) 01/2018
1	Congenital Abnormalities (Deformity) 11/2017
1	Trisomy (Trisomies) 01/2017
1	Pulpitis 01/2016
1	Liver Diseases (Liver Disease) 09/2015
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 05/2015
1	Goldenhar Syndrome (Hemifacial Microsomia) 01/2014
1	Nephritis 01/2012
1	Craniofacial Dysostosis (Crouzon Disease) 04/2011
1	Synostosis 04/2011
1	Craniosynostoses (Craniosynostosis) 04/2011
1	Tongue Diseases 05/2010
1	Odontogenic Tumors (Dental Tissue Neoplasm) 10/2009
1	Ameloblastoma 10/2009
1	Bone Resorption 02/2008
1	Papillon-Lefevre Disease 05/2002
1	Periodontitis 05/2002
1	Cleft Lip (Harelip) 01/2002

Drug/Important Bio-Agent (IBA)

3	Proteins (Proteins, Gene)FDA Link 10/2021 - 10/2009
3	Dihydroorotate DehydrogenaseIBA 01/2016 - 12/2012
2	CytokinesIBA 02/2008 - 05/2002
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 10/2021
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 10/2021
1	Conditioned Culture MediaIBA 10/2021
1	Sialic Acid Binding Immunoglobulin-like LectinsIBA 10/2021
1	Adenosine Triphosphate (ATP)IBA 11/2019
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 11/2019
1	Messenger RNA (mRNA)IBA 11/2019
1	Culture MediaIBA 11/2019
1	Copper-Transporting ATPasesIBA 01/2019
1	CopperIBA 01/2019
1	Pamidronate (Aredia)FDA LinkGeneric 11/2018
1	Dopamine (Intropin)FDA LinkGeneric 08/2018
1	Methyl-CpG-Binding Protein 2IBA 01/2018
1	Biogenic Amines (Biogenic Amine)IBA 01/2018
1	Mitochondrial DNA (mtDNA)IBA 11/2017
1	Adrenal Cortex Hormones (Corticosteroids)IBA 11/2017
1	Interferon-gamma (Interferon, gamma)IBA 01/2016
1	Therapeutic UsesIBA 09/2015
1	Biological ProductsIBA 09/2015
1	Carbon Tetrachloride (Tetrachloromethane)IBA 09/2015
1	Interleukin-17 (Interleukin 17)IBA 05/2015
1	DNA (Deoxyribonucleic Acid)IBA 01/2014
1	pyrimidineIBA 02/2013
1	AutoantibodiesIBA 01/2012
1	Transforming Growth Factor-beta Type II ReceptorIBA 05/2010
1	tuftelin (enamelin)IBA 10/2009
1	Heparin (Liquaemin)FDA LinkGeneric 10/2009
1	AdiponectinIBA 02/2008
1	Enflurane (Ethrane)FDA LinkGeneric 01/2002

Therapy/Procedure

4	Transplantation 04/2019 - 01/2012
2	Liver Transplantation 11/2018 - 09/2015
1	Intravenous Injections 10/2021
1	Stem Cell Transplantation 04/2019
1	Ligation 12/2018
1	Therapeutics 01/2017
1	Sutures (Suture) 04/2011